scientific

Scientist of the day

Today we’re going to talk about a very special woman named Gerty Cori. Those of you who’ve ever had a biochemistry course have probably already heard of the Cori cycle to which this woman contributed to. So let’s talk about her!

Gerty Theresa Radnitz was her maiden name. She was born in 1847 in what is now known as Czech-Republic. She got admitted to medical school at the Karl-Franz university in 1914 where she met her husband Carl Cori.
Due to anti-semitism in Europe the couple moved to the U.S. and became naturalized citizens. They both worked in a laboratory and investigated the carbohydrate metabolism.
What’s quite striking is that universities wanted Carl Cori to work for them, but not Gerty. Despite these unfortunate events they kept working together however it took Gerti longer to get the same wage and position as her husband had. She was made a professor in 1943 at Washington university (where she’d worked since 1931).

They discovered the Cori cycle for which they got half of the Nobel Prize in medicine or physiology in 1947. The other half went to Bernardo Houssay.
The Cori cycle describes how glycogen is converted to lactic acid and then reconverted to glucose.

She died in 1957 due to myelosclerosis.

Scientist of the day

Today I wanted to switch things up and start” scientist of the day”. I will try to do one of these post every once in a while to highlight a scientist who has done remarkable research in the field of medicine.

The first scientist featured in this series is Gerhard Domagk. He was born in 1895 in what is now known as Poland. He studied medicine but the war started and without finishing his degree he volunteered as soldier. When he got injured he ended up in a war hospital where he saw most soldiers die of infection diseases. What really made an impact was that there really was no functional treatment for these diseases. Surgery didn’t always work nor did medication.
After the war he got his degree in medicine and made it his priority to find something that could prevent soldiers dying from these infection diseases. He worked alongside Josef Klarer and Fritz Mietzsch and tested the function of hundreds of molecules in mice and rabbits.
Eventually in 1932 they found a component in red dye that was called sulfamidochrysoïdine which is broken down by the body to sulfanilamide and protected mice against certain types of streps. They named it Prontosil.
What was really unexpected is that it took them 5 years to publish an article talking about the amazing results Prontosil had had in patients because they didn’t know how/why Prontosil functioned which made them quite cautious.
In 1939 Domagk received the nobel price in physiology or medicine. He couldn’t collect this prize because the Nazi-regime considered the Nobel prize to be anti-German. He finally collected the prize in 1947.

I hope you enjoyed this post! If you want to learn more about infection diseases and the history behind them I’d strongly recommend reading ‘the demon under the microscope’ written by Thomas Hager. The book is about many different scientists.

Lots of love
-A doctor in spe

 

Medical article databases

One of the most important fields in medicine is research. This should come as no surprise as there’s still so much to learn about the human body and disorders related to it. As a medical student it’s extremely important to stay up to date and read in on these subjects and to learn more about the (r)evolutions in our health system.
There are a lot of databases where you’ll be able to find articles on medical research and today I’ll be talking about the best general databases.

1. Google Scholar

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Google scholar is most definitely the best way to find the most scientific articles on any subject. You’ll be able to view the number of citations (a value to determine the impact) as well as the journal where the article was published and the publication year.
There is one thing I dislike about using google scholar. The filter system is quite impractical. Nevertheless you’ll be able to find a lot of articles extending over many different scientific topics. Google scholar will also show the number of citations, journal where the article was published and the publication year.

2. PubMed

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PubMed has a lot of different features and therefore learning how to work with the system is a challenge on itself. You’ll have to navigate your way around MeSH-terms and the search builder, subject topics etc, however when you finally know how to work with it, it’s actually a pretty nice database to work with.
You will definitely not find as many articles as you would in Google Scholar, however there is a good amount of articles that are closely related to your topic of choice. The filters are easy to use and will help you to narrow your topic down more clearly.

3. Embase
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One of the more esthetically pleasing databases is Embase (yes, I really like Embase). It’s easy to use and works similar to PubMed but you search via Emtree terms instead of MeSH terms. You can view your previous search inquiries and the amount of articles related to it.

4. Extra
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I also wanted to talk about Web of science where you’ll be able to find the impact factor, the number of citations. This is an easy way to have an overview on the importance of your article as well as the journal it was published in.

P.S. I prefer to use general databases as they offer a great variation of articles but if you only want to read the most important articles on certain subjects you might want to take a look at different options such as Medline, TRIP, Cochrane etc.

I hope you enjoyed this article! Let me know what sources you turn to to find scientific articles.

Lots of love
-M. Doctor in spe